The Southeast Collaboratory for Structural Genomics: A High-Throughput Gene to Structural Factory

Structural genomics and high-throughput

Structural genomics and high-throughput structural biology

✍ Gale Rhodes 📂 Article 📅 2007 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 83 KB 👁 1 views

Analysis of the genomic structure of the

Analysis of the genomic structure of the human glycine receptor ?2 subunit gene and exclusion of this gene as a candidate for Rett syndrome

✍ Cummings, Chris J.; Dahle, E. Jill Roth; Zoghbi, Huda Y. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 28 KB 👁 2 views

The gene that encodes the human ␣2 subunit of the inhibitory glycine receptor (GLRA2) is located on the X chromosome (Xp22.2) in a candidate region for a number of neurological disorders. Recently, an exclusion mapping strategy identified this region to be concordant in familial Rett syndrome (RTT)

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

The High-Resolution Solution Structure o

The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Most of the drugs available today for the treatment of cancer are based on the inhibition of cell proliferation and induction of cell death by apoptosis. At the molecular level, the majority of cytotoxic agents interfere with DNA function. However, a prominent subclass of compounds, including paclit

Human KLRF1, a novel member of the kille

Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis

✍ Pedro Roda-Navarro; Ignacio Arce; Mónica Renedo; Kate Montgomery; Raju Kucherlap 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB 👁 2 views

Titelbild: The High-Resolution Solution

Titelbild: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. 22/2003)

✍ Teresa Carlomagno; Marcel J. J. Blommers; Jens Meiler; Wolfgang Jahnke; Thomas S 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB 👁 2 views

**Leistungsstarke Tumortherapeutika** der Epothilon‐Familie wirken durch Bindung an Tubulin und Beeinflussung der Microtubuli‐Entwicklung. Bisher sind keine hochaufgelösten Strukturen von Tubulin‐Epothilon‐Komplexen verfügbar, doch ließen sich NMR‐spektroskopisch zwei größere Konformationsänderungen