The source of choline for acetylcholine synthesis in brain
โ Scribed by John J. Freeman; Donald J. Jenden
- Book ID
- 118937521
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- English
- Weight
- 839 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0024-3205
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The metabolism of choline by rat brain, plasma, and liver was investigated using combined gas chromatography mass spectrometry following microwave irradiation and treatment with deuterium-labeled choline. Methods were established to measure simultaneously the concentrations of six choline-containing
Endogenous free choline levels and acetylcholine (ACh) synthesis in nerve terminals were investigated using cerebral cortical synaptosomes of C57BL/6 mice. Endogenous choline was produced at a rate tenfold faster than ACh to provide levels adequate for the formation of the latter. The combined pool