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The Solubility–Permeability Interplay: Mechanistic Modeling and Predictive Application of the Impact of Micellar Solubilization on Intestinal Permeation

✍ Scribed by Miller, Jonathan M.; Beig, Avital; Krieg, Brian J.; Carr, Robert A.; Borchardt, Thomas B.; Amidon, Gregory E.; Amidon, Gordon L.; Dahan, Arik


Book ID
118129931
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
949 KB
Volume
8
Category
Article
ISSN
1543-8384

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The solubility–permeability interplay in
✍ Arik Dahan; Jonathan M. Miller; Amnon Hoffman; Gregory E. Amidon; Gordon L. Amid 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB

A quasi-equilibrium mass transport analysis has been developed to quantitatively explain the solubility-permeability interplay that exists when using cyclodextrins as pharmaceutical solubilizers. The model considers the effects of cyclodextrins on the membrane permeability (P(m)) as well as the unst