The solubility–permeability interplay in
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Arik Dahan; Jonathan M. Miller; Amnon Hoffman; Gregory E. Amidon; Gordon L. Amid
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Article
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2010
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John Wiley and Sons
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English
⚖ 212 KB
A quasi-equilibrium mass transport analysis has been developed to quantitatively explain the solubility-permeability interplay that exists when using cyclodextrins as pharmaceutical solubilizers. The model considers the effects of cyclodextrins on the membrane permeability (P(m)) as well as the unst