Solid support synthesis of 14- and 17-me
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Alexander S. Kiselyov; Leon Smith II; Paul Tempest
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Article
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1999
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Elsevier Science
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French
โ 702 KB
Efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4nitrobenzoic acid with the OH of 3-hydroxytyrosine on solid support is reported. The flexibility of this synthesis, as wel1 as the excellent purity (>90%) of the final products are the distinctive characteristi