The sodium pump of erythrocytes from patients with duchenne muscular dystrophy: Effect of ouabain on the active sodium flux and on (Na+,K+)ATPase

✍ Scribed by Gilbert Souweine; Jean Claudius Bernard; Yves Lasne; Jean Lachanat

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 439 KB
• Volume: 217
• Category: Article
• ISSN: 0340-5354
• DOI: 10.1007/bf00312990

✦ Synopsis

Active ion exchanges across erythrocyte membrane from patients with Duchenne muscular dystrophy were studied by two methods: --erythrocyte ghosts (Na+,K+)ATPase activity and its sensibility to ouabain, using an enzymatic method; --active sodium outflux and its sensibility to ouabain using a radioisotopic method. (Na+,K+)ATPase activity and active sodium outflux were decreased in dystrophic patients compared to normal sex- and age-matched controls. Enzymatic activity and active sodium outflux were inhibited by ouabain 10(-4) M in patients and in controls. Inhibition of the active sodium outflux was lower in patients than in controls. The results are discussed in light of the literature.