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The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia

✍ Scribed by Daniel J. Müller; Tim A. Klempan; Vincenzo De Luca; Tricia Sicard; Jan Volavka; Pal Czobor; Brian B. Sheitman; Jean-Pierre Lindenmayer; Leslie Citrome; Joseph P. McEvoy; Jeffrey A. Lieberman; William G. Honer; James L. Kennedy

Book ID: 116767460
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 110 KB
Volume: 379
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2004.12.037

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## Abstract ## Objective Atypical antipsychotic drugs, in particular clozapine and olanzapine, influence cellular lipogenesis and are associated with metabolic side effects including weight gain. Insulin induced gene 2 (INSIG2) mediates feedback control of lipid synthesis and polymorphisms in the