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The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

✍ Scribed by Yerbury, Justin J.; Gower, Dane; Vanags, Laura; Roberts, Kate; Lee, Jodi A.; Ecroyd, Heath

Book ID
115496787
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
429 KB
Volume
18
Category
Article
ISSN
1355-8145

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## Abstract The heat‐shock proteins (HSPs) Hsp27 and αB‐crystallin are up‐regulated in Alzheimer's disease (AD), but the extent of this and the consequences are still largely unknown. The HSPs are involved in protein degradation and protection against protein aggregation, and they interact with sev