The c-met proto-oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects on cell growth and motility, HGF may be important in the development of cancer metastases in hepatocellular carcinoma (
The significance of proto-oncogene HGF/SF receptor c-Met mRNA expression in nasopharyngeal carcinoma
โ Scribed by Chongmei Liu; Zhiming Liu; Minzheng Ying; Minghui Lin; Jie Wang; Ming Mao
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 270 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1610-1979
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
mal and malignant epithelial cells and several other cell The c-met proto-oncogene encodes the tyrosine kinase types, including endothelial cells and melanocytes. 4,5 receptor for hepatocyte growth factor (HGF), a potent It has been reported that the expression of c-Met is enmitogen and motogen for
Hepatocyte growth factor/scatter factor (HGF/SF) induces cell motility and tissue remodeling of various epithelial cells through its receptor, the product of the proto-oncogene c-met. High levels of HGF/SF have been correlated with poor prognosis in human breast carcinoma. In this study, we examined