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The significance of in vitro studies on peroxisome proliferation

✍ Scribed by Bieri, F.; Muakkassah-Kelly, S.; Waechter, F.; Sagelsdorff, P.; Stäubli, W.; Bentley, P.

Book ID
122399925
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
412 KB
Volume
4
Category
Article
ISSN
0887-2333

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## Abstract The hepatocarcinogenicity of peroxisome proliferators (PPs) in rodents has been attributed both to oxidative DNA damage resulting from excessive leakage of peroxisomal H~2~O~2~ and to increased hepatocellular replication that may be independent of peroxisome proliferation. Because of th