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The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients

โœ Scribed by Dandan Liu; Zixing Chen; Yongquan Xue; Dingwei Lu; Youning Zhou; Jingxia Gong; Weilin Wu; Jianying Liang; Qinfen Ma; Jinlan Pan; Yafang Wu; Yong Wang; Jun Zhang; Juan Shen

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
683 KB
Volume
33
Category
Article
ISSN
0145-2126

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โœฆ Synopsis

Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P<0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities.

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