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The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine

โœ Scribed by Kelli R. Rodvelt; Clark E. Oelrichs; Lucas R. Blount; Kuo-Hsien Fan; Susan Z. Lever; John R. Lever; Dennis K. Miller

Book ID
116412807
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
730 KB
Volume
116
Category
Article
ISSN
0376-8716

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In this study, we examined the effect of the acute and repeated administration of the selective sigma () 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA4503) on the number and firing pattern of spontaneously active dopamine (DA) neurons in substantia ni