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The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions

✍ Scribed by QU, Cheng Kui

Book ID
110020420
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
103 KB
Volume
10
Category
Article
ISSN
0007-0610

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## Abstract Interleukin‐1Ξ² (IL‐1Ξ²) mediates destruction of matrix collagens in diverse inflammatory diseases including arthritis, periodontitis, and pulmonary fibrosis by activating fibroblasts, cells that interact with matrix proteins through integrin‐based adhesions. In vitro, IL‐1Ξ² signaling is