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The short isoform of the long-type PML-RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all-trans-retinoic acid

✍ Scribed by Tan, Yanhong; Bian, Sicheng; Xu, Zhifang; Chen, Xiuhua; Qi, Xiling; Ren, Fanggang; Li, Li; Guo, Haixiu; Xu, Aining; Zhang, Linlin; Wang, Hongwei

Book ID: 120862226
Publisher: John Wiley and Sons
Year: 2013
Tongue: English
Weight: 312 KB
Volume: 162
Category: Article
ISSN: 0007-1048
DOI: 10.1111/bjh.12362

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In vitro response to all-trans retinoic

In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes

✍ Marie-Joëlle Mozziconacci; Concetta Liberatore; Véronique Brunel; Francesco Grig 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 941 KB

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) cytogenetic abnormality leading to the expression of two fusion genes, PML/RARA and RARA/PML, and by its sensitivity to all-trans retinoic acid (ATRA) differentiating treatment. Rare APL cases lacking the t(15;17) have been describe