The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

Activation of p42/p44 mitogen-activated

Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2α in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms

✍ Øyvind Melien; G. Hege Thoresen; Dagny Sandnes; Eva Østby; Thoralf Christofferse 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 3 views

Several agents that act through G-protein-coupled receptors and also stimulate phosphoinositide-specific phospholipase C (PI-PLC), including angiotensin II, vasopressin, norepinephrine, and prostaglandin (PG) F 2a , activated the ERK1 (p44 mapk ) and ERK2 (p42 mapk ) members of the mitogen-activated