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The Shed Ectodomain of Collagen XVII/BP180 Is Targeted by Autoantibodies in Different Blistering Skin Diseases

✍ Scribed by Hauke Schumann; Jens Baetge; Kaisa Tasanen; Fenella Wojnarowska; Heike Schäcke; Detlef Zillikens; Leena Bruckner-Tuderman

Book ID: 117022368
Publisher: American Society for Investigative Pathology
Year: 2000
Tongue: English
Weight: 496 KB
Volume: 156
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64772-4

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## Background: Type xvii collagen promotes adhesion of basal keratinocytes to epidermal basement membrane, and is the target of disease in patients with certain inherited or acquired blistering diseases. two forms of type xvii collagen are produced by cultured human keratinocytes: a 180-kda full-le