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The SHB adapter protein is required for efficient multilineage differentiation of mouse embryonic stem cells

✍ Scribed by Vitezslav Kriz; Cecilia Annerén; Cheng Lai; Jacob Karlsson; Jaroslav Mares; Michael Welsh


Book ID
117099819
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
457 KB
Volume
286
Category
Article
ISSN
0014-4827

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## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference