Cdk1 is required for the self-renewal of
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Wei Wei Zhang; Xiao Jie Zhang; Hui Xian Liu; Jie Chen; Yong Hong Ren; Deng Gao H
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Article
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2011
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John Wiley and Sons
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English
⚖ 277 KB
## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference