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The shared epitope and severity of rheumatoid arthritis

✍ Scribed by Gorman, Jennifer D; Criswell, Lindsey A


Book ID
122968440
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
452 KB
Volume
28
Category
Article
ISSN
0889-857X

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## Abstract ## Objective Susceptibility to rheumatoid arthritis (RA) is closely associated with __HLA–DRB1__ alleles encoding a shared epitope (SE) in positions 70–74 of the HLA–DRΞ² chain. The mechanistic basis for this association is unknown. Given the proposed pathogenic role of nitric oxide (NO