The sequence-specific nuclear matrix binding factor F6 is a chicken GATA-like protein
✍ Scribed by Vassetzky, Y. S. ;De Moura Gallo, C. V. ;Bogdanova, A. N. ;Razin, S. V. ;Scherrer, K.
- Book ID
- 104707783
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 930 KB
- Volume
- 238
- Category
- Article
- ISSN
- 0026-8925
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✦ Synopsis
The sequence-specific DNA-binding protein factor F6, which binds upstream of the cluster of the chicken alpha-globin genes, has previously been found to interact with a DNA fragment containing a replication origin and a nuclear matrix binding site. This protein has been partially characterized. Based on its molecular weight and binding affinity, F6 belongs to a family of GATA proteins, the chicken equivalent of transcription factor NFE-1. An oligonucleotide including the binding site for F6 competes for binding of the above-mentioned DNA fragment to the nuclear matrix. This indicates an involvement of this protein in the interaction between DNA and the nuclear matrix.