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The sequence of revascularization in liver transplantation: It does make a difference

✍ Scribed by Wojciech G. Polak; Robert J. Porte


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
75 KB
Volume
12
Category
Article
ISSN
1527-6465

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✦ Synopsis


No consensus exists regarding the most optimal sequence of revascularization of the liver graft during liver transplantation. The current methods of revascularization of the liver graft can be divided into 2 main groups (Table 1). The first group is sequential revascularization, in which the graft is first reperfused via either the portal vein or the hepatic artery (anterograde reperfusion), or via the inferior vena cava (IVC) (retrograde reperfusion), with subsequent reconstruction of the remaining vessels. The second group is simultaneous revascularization, in which the graft is reperfused simultaneously via the portal vein and hepatic artery. Experimental as well as clinical studies comparing different methods of revascularization are still scarce, results are not always unequivocal, and endpoints differ largely between different studies. Nevertheless, some important messages can be extracted from the current literature.

EXPERIMENTAL STUDIES

Various reperfusion protocols have been analyzed in 3 experimental studies, using different animal models. [1][2][3] Hickman and Innes 1 compared 2 sequential protocols in pigs: initial arterial revascularization (IAR) vs. initial portal revascularization (IPR). These investigators found better homogenous perfusion of the liver graft after IAR, compared to IPR. However, there were no differences in posttransplantation aspartate aminotransferase serum levels among the 2 groups. van As et


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