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The sequence of a 21·3kb DNA fragment from the left arm of yeast chromosome XIV revealsLEU4, MET4, POL1, RAS2, and six new open reading frames

✍ Scribed by Saiz, Julia E.; Buitrago, Maria J.; Soler-mira, Aida; Del Rey, Francisco; Revuelta, José L.

Book ID
102648022
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
594 KB
Volume
12
Category
Article
ISSN
0749-503X

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✦ Synopsis

The nucleotide sequence of a fragment of 21 308 bp from the left arm of S~icclruroiqws cerevisiae chromosome XIV has been detemiined. Analysis of the sequence revealed 13 open reading frames (ORFs) longer than 300 bp, four of which correspond to the previously identified genes LEU4, MET4, POLl and RAS2. One putative protein, N2160, shares considerable homology (32°C identity) with a hypothetical protein encoded by a gene located on Chromosome XV as well as with human OCRL protein (36% identity), involved in Lowe's syndrome. N2185 contains ten predicted transmembrane segments and is similar to another putative protein (YKL146) from yeast, The sequence of the reported DNA fragment has been submitted to the EMBL data library under Accession Number 250161.

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