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The sensitivity of magnetic resonance image signals of a rat brain to changes in the cerebral venous blood oxygenation

✍ Scribed by Seiji Ogawa; T. M. Lee; Bertrand Barrere

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
655 KB
Volume
29
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The sensitivity of magnetic resonance image signals of the brain to the change in the cerebral blood oxygenation was measured in gradient echo images of rat brains at a field strength of 7 T. The sensitivity depended on the blood vessel volume relative to the tissue volume within the image voxel, and signal intensities in the cortical area were well correlated with the change in the venous blood de‐oxygenation level at the sagittal sinus. Tissue signals in the image (15 ms echo time) showed a sensitivity of 10‐20% change for the full range of deoxygenation level from 0‐100%. From these observations and image simulations, the extent of the signal response to some neuro‐stimulation which induces an increase in regional cerebral blood flow has been estimated for 4 T field strength.

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