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The selective introduction of organometallic markers into estrogens. A-ring propargylation of β-estradiol

✍ Scribed by S Greenfield; M Gruselle; G Jaouen; V Varghese; K M Nicholas

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 350 KB
Volume: 1
Category: Article
ISSN: 0268-2605
DOI: 10.1002/aoc.590010509

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✦ Synopsis

Introduction of the propargyl dicobalt hexacar-bony1 moiety onto the estradiol A ring as a potential probe in receptor studies requires protection of the ring phenolic group, and the regioselectivity of the attack (2-versus 4-position) depends on the bulkiness of the organometallic carbenium ion.

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