The second generation synthesis of a tumor promoter pendolmycin
โ Scribed by Kazuaki Okabe; Mitsutaka Natsume
- Book ID
- 108371964
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 874 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0040-4020
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A synthetic pathway is presented to a functionalized pseudopeptide molecular platform for use in supramolecular and solution-phase combinatorial chemistry. The platform contains amino acids with quaternary asymmetric centers, the conยฎgurations of which are determined by the method of synthesis.
## Abstract In this article, a Lewis acid mediated 1,4โaddition/formal [3+2] cycloaddition reaction engaging functionalized ฮฒโcarboline and 1,4โbenzoquinone has been demonstrated. Application of this developed technology facilitated the construction of the challenging Cโ9โฒโCโ15 quaternary center li