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The search for orally active medications through combinatorial chemistry

✍ Scribed by Robert A. Fecik; Kristine E. Frank; Elmer J. Gentry; Sanjay R. Menon; Lester A. Mitscher; Hanumaiah Telikepalli

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 504 KB
Volume: 18
Category: Article
ISSN: 0198-6325
DOI: 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x

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✦ Synopsis

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.

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