More is less: Inactivation and deletion
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W. Edward C. Bradley; Domenic Di Paola; Emmanouil Rampakakis; Maria Zannis-Hadjo
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Article
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2010
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John Wiley and Sons
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English
β 115 KB
## Abstract Tumor suppressor genes are frequently inactivated in cancer by largeβscale deletion events or epigenetic silencing, and experimental demonstration of such inactivation has historically been considered as support for assigning tumor suppressive function to a given gene. However, the disc