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The search and prime hypothesis for growth cone turning

✍ Scribed by Søren S.L. Andersen

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
152 KB
Volume
27
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

In the fields of axonal and dendritic guidance, there is now a significant accumulation of knowledge of how extracellular signaling molecules activate their cognate growth cone receptors. Relatively little is known about the subsequent activation of intracellular signaling pathways and actin reorganization, and very little is known about how microtubules (MTs) reorganize during growth cone turning. I hypothesize that dynamic MTs are required in order to catalyze the polarized actin assembly necessary for growth cone turning, that MTs and actin filaments promote each other's assembly through positive feedback, that MT stability is enhanced further through the formation of membrane-associated MT attachment sites, and that these MT stabilization events subsequently accelerate axonal/dendritic shaft formation. BioEssays 27: 86-90, 2005.

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