Chromosomal instability is a characteristic feature of hepatocellular carcinoma (HCC) but its origin and role in liver carcinogenesis are undefined. We tested whether a defect in the nonhomologous end-joining (NHEJ) DNA repair gene Ku70 was associated with chromosomal abnormalities and enhanced live
The scid mutation in mice causes a general defect in DNA repair
β Scribed by Fulop, G. M.; Phillips, R. A.
- Book ID
- 109766053
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 455 KB
- Volume
- 347
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/347479a0
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The hush puppy mouse mutant has been shown previously to have skull and outer, middle, and inner ear defects, and an increase in hearing threshold. The fibroblast growth factor receptor 1 (__Fgfr1__) gene is located in the region of chromosome 8 containing the mutation. Sequencing of the gene in hus
Patient TTD183ME is male and has typical trichothiodystrophy characteristics, including brittle hair, ichthyosis, characteristic face with receding chin and protruding ears, sun sensitivity, and mental and growth retardation. The relative amount of NER carried out by a TTD183ME fibroblast cell strai