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The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells

✍ Scribed by Mihaela Marina, Limin Wang, Susan E Conrad


Book ID
119904622
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
588 KB
Volume
10
Category
Article
ISSN
1478-811X

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## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept