✦ LIBER ✦
The same “TATA” box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation
✍ Scribed by Shangzhi Huang; Corinne Wong; Stylianos E. Antonarakis; Tsai Ro-lien; Wilson H. Y. Lo; Haig H. Kazazian
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 271 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
A Chinese beta +-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position -29 in the TATA box of the beta-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.