The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate

✍ Scribed by H. Knauf; W. Cawello; G. Schmidt; E. Mutschler

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 522 KB
• Volume: 46
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00195908

✦ Synopsis

The effect of the thiazide diuretic, bemetizide, on the excretion of Na +, K +, CI-, Ca 2 +, and Mg 2 ÷ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged from 133 to 5 ml. min-1.

After a 2-day fluid and salt balanced control period, 25 mg bemetizide given orally induced natriuresis and kaliuresis which lasted for 24 h and were proportional to the GFR of the patients. The ratio of bemetizide-induced K+/Na ÷ excretion was always 0.17 irrespective of individual GFR. In renal failure, bemetizide increased the fractional Na + excretion from 3 % to about 10 %. Kaliuresis was associated with magnesiuria, whereas bemetizide-induced calciuresis was insignificant. The thiazide reversibly lowered GFR in all subjects.