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The Runx2 transcription factor plays a key role in the 1α,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells

✍ Scribed by Roberto Paredes; Gloria Arriagada; Fernando Cruzat; Juan Olate; Andre van Wijnen; Jane Lian; Gary Stein; Janet Stein; Martin Montecino

Book ID
116697377
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
130 KB
Volume
89-90
Category
Article
ISSN
0960-0760

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## Abstract The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1α,25 dihydroxy vitamin D3, Runx2 may interact with the 1α,25 dihydroxy vitamin D3 receptor (VDR) in the promoter of target genes, producing a synergic activation of their transcription. Prev