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The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme

✍ Scribed by Kee, Younghoon; Lyon, Nancy; Huibregtse, Jon M


Book ID
110031104
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
298 KB
Volume
24
Category
Article
ISSN
0261-4189

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## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r