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The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders

✍ Scribed by Ranran Zhang; Mithun Vinod Shah; Thomas P. Loughran Jr

Book ID
102253563
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
148 KB
Volume
28
Category
Article
ISSN
0278-0232

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✦ Synopsis

Abstract

Large granular lymphocytes (LGL) leukaemia can arise from either natural killer (NK) cells or cytotoxic T lymphocytes (CTL). The T‐cell form of LGL leukaemia has significant overlap with other haematological disorders and autoimmune diseases. Here we provide an overview of LGL biology. We also focus discussion on the indolent LGL leukaemia related disorders and their causal relationships. We then discuss the potential relationships and distinctions between indolent LGL leukaemia and non‐malignant clonal lymphocyte expansion that occur in otherwise healthy individuals, especially elder people. Copyright Β© 2009 John Wiley & Sons, Ltd.

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## Abstract As a rule, T cell large granular lymphocyte (T‐LGL) leukemia runs a chronic clinical course without need for therapy. Some cases, however, progress to an aggressive disease after the indolent clinical stage. The transformation mechanism into a high‐grade malignancy has not been well stu