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The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis

✍ Scribed by Keith D Brown, Estefania Claudio, Ulrich Siebenlist


Book ID
120706675
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
439 KB
Volume
10
Category
Article
ISSN
1478-6354

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## Abstract To analyze the role of the classical and alternative pathways of complement activation in the effector phase of arthritis, we have induced arthritis in C3‐ and factor B (FB)‐deficient (C3^–/–^ and FB^–/–^) DBA/1J mice using well‐defined monoclonal IgG2b and IgG2a antibodies to type II c