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The roles of PCNA SUMOylation, Mms2-Ubc13 and Rad5 in translesion DNA synthesis in Saccharomyces cerevisiae

✍ Scribed by Agnieszka Halas; Agnieszka Podlaska; Joanna Derkacz; Justyna McIntyre; Adrianna Skoneczna; Ewa Sledziewska-Gojska


Book ID
110836922
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
586 KB
Volume
80
Category
Article
ISSN
0950-382X

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr