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The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury

✍ Scribed by T. P. Monteiro; K. B. El-Jaick; A. L. Jeovanio-Silva; P. E. A. A. Brasil; M. J. M. Costa; V. C. Rolla; L. de Castro


Book ID
119835539
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
497 KB
Volume
37
Category
Article
ISSN
0269-4727

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## Abstract The pathogenesis of immune‐mediated drug‐induced liver injury (DILI) following halogenated anesthetics, carbamazepine or alcohol has not been fully elucidated. Detecting cytochrome P450 2E1 (CYP2E1) IgG4 auto‐antibodies in anesthetic DILI patients suggests a role for IL‐4 in this hapten