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The roles of Fas and perforin in LAK T-cell/bispecific antibody-mediated killing of the murine B-lymphoma cells, BCL1

✍ Scribed by John M. Armstrong; Ellen S. Vitetta

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 503 KB
Volume: 68
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19961211)68:6<822::aid-ijc22>3.0.co;2-0

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✦ Synopsis

The aim of this study was to construct bispecifc F(ab')l [antLCD3 X anti-BCL, idiotype (Id)] Abs (BsAbr) which would enable Iymphokine-activated killer (IAK) T cells to kill Id+ mouse BCL, lymphoma cells, and to determine the mechanism(s) underlying cell death. Using 4-day activated LAK T cells from either perforin-knockout mice or FasL-deficient gld mice, we show that the Fas pathway, but not perforin, is required for BsAb-mediated LAK T-cell-induced killing of BCL, cells.

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