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The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2

✍ Scribed by Shizuo Narimatsu; Kimio Kiryu; Rei Yonemoto; Manabu Yoshino; Mitsuko Kobatake; Daichi Kazamori; Saori Hagino; Kazufumi Masuda; Takashi Katsu; Masato Asanuma; Takuya Kumamoto; Tsutomu Ishikawa; Yoshihiko Funae; Shigeru Yamano; Nobumitsu Hanioka; Shinsaku Naito

Book ID
113517614
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
662 KB
Volume
172
Category
Article
ISSN
0009-2797

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πŸ“œ SIMILAR VOLUMES

Roles of phenylalanine at position 120 a
Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6
✍ Kazufumi Masuda; Keietsu Tamagake; Takashi Katsu; Fumihiro Torigoe; Keita Saito; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 350 KB

## Abstract The roles of Phe‐120 and Glu‐222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wild‐type CYP2D6 (CYP2D6‐WT) oxidized BTL to 4‐hydroxybunitrolol (4‐OH‐BTL) with substrate enantioselectivity of (__R__)‐(+)‐BTL > (__S__)‐(βˆ’)‐BTL. The sam