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The role of zinc in 5′,5′-diadenosine tetraphosphate production by aminoacyl-transfer RNA synthetases

✍ Scribed by Sylvain Blanquet; Pierre Plateau; Annie Brevet

Book ID: 104674193
Publisher: Springer
Year: 1983
Tongue: English
Weight: 506 KB
Volume: 52
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00230583

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✦ Synopsis

Aminoacyl-tRNA synthetases are capable of converting 5'-ATP into 5',5'-diadenosine tetraphosphate. The reaction reflects the reversal of enzyme-bound aminoacyl-adenylate by ATP instead of PPi. In the case of a few prokaryotic as well as eukaryotic aminoacyl-tRNA synthetases, the initial rate of diadenosine tetraphosphate synthesis can be greatly enhanced upon adding small amounts of zinc. This observation enables us to establish a relationship between diadenosine tetraphosphate, a nucleotide possibly involved in controlling cell proliferation, and a metallic cofactor, which is believed to play a role in tumour growth.

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