In the present work we have modelled and optimized the reaction mechanism of the triose phosphate isomerase (TIM) enzyme (E.C. 5.3.1.1). For this purpose we have used an approach that combines the S-system representation within the power law formalism and linear programming techniques. By this means
✦ LIBER ✦
The Role of Water in the Catalytic Efficiency of Triosephosphate Isomerase †,‡
✍ Scribed by Zhang, Zhidong; Komives, Elizabeth A.; Sugio, Shigetoshi; Blacklow, Stephen C.; Narayana, Narendra; Xuong, Nguyen H.; Stock, Ann M.; Petsko, Gregory A.; Ringe, Dagmar
- Book ID
- 119945023
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 167 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0006-2960
No coin nor oath required. For personal study only.
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In submitting this article to the new IUBMB Life series, I no doubtfully will scoop numerous giants in the field and claim triosephosphate isomerase (TIM) to be ''My Favorite Enzyme''! My first introduction to this remarkable enzyme came during my graduate studies in the laboratory of Victor L.
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