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The role of viral fitness in HIV pathogenesis

✍ Scribed by Jason D. Barbour; Robert M. Grant

Publisher
Springer
Year
2005
Tongue
English
Weight
208 KB
Volume
2
Category
Article
ISSN
1548-3568

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Viral and host factors in the pathogenes
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✍ Cynthia A Derdeyn; Guido Silvestri πŸ“‚ Article πŸ“… 2005 πŸ› Elsevier Science 🌐 English βš– 161 KB

Recent studies suggest that the pathogenesis of HIV infection and AIDS involves two distinct phases. During acute infection, massive depletion of CD4 + CCR5 + memory T cells within the mucosal-associated lymphoid tissue leads to major and potentially irreversible damage to CD4 + T-cell-mediated immu