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The role of tryptophan residues in heparin-antithrombin interactions

✍ Scribed by George I. Karp; James A. Marcum; Robert D. Rosenberg


Book ID
115706273
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
828 KB
Volume
233
Category
Article
ISSN
0003-9861

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## Abstract We evaluated the role of nonspecific electrostatic binding in the interaction of antithrombin (AT) with heparin (Hp), a paradigmatic protein‐glycosaminoglycan (GAG) system. To do so, we obtained the ionic‐strength dependence of the binding constant, since a common feature in protein‐pol