The role of transforming growth factor-β 2 and 3 in formation of ventral body wall in the cadmium-induced omphalocele chick model
✍ Scribed by Takashi Doi; Prem Puri; John Bannigan; Jennifer Thompson
- Book ID
- 116688359
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 187 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-3468
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We have investigated the role of autocrine/paracrine TGF-b secretion in the regulation of cell growth by androgens as demonstrated by its inhibition by two androgen response modifiers; the nonsteroidal antiandrogen hydroxyflutamide (OHF), believed to act by inhibiting androgen binding to androgen re
## Abstract ## Objective To investigate in vivo and in vitro whether macrophages have an intermediate role in transforming growth factor β (TGFβ)–induced osteophyte formation. ## Methods In vivo, synovial lining macrophages were selectively depleted by injection of clodronate‐laden liposomes 7 d