The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation

✍ Scribed by Carlo Rossetti, Francesco Peri

Publisher: Springer International Publishing;Springer
Year: 2021
Tongue: English
Leaves: 179
Series: Progress in Inflammation Research 87
Edition: 1st ed.
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs).

This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates in agonism/antagonism as well as the pivotal role of the CD14 receptor in the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade.

The book presents the role of TLR4 in several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), in neurodegenerative and neurological diseases such as Parkinson and Alzheimer’s diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 in neural stem cell-mediated neurogenesis and neuroinflammation and in Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.

✦ Table of Contents

Front Matter ....Pages i-xi
Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine Adjuvant (Atsushi Shimoyama, Koichi Fukase)....Pages 1-19
Intracellular TLR4 Signaling (Nikolay N. Kuzmich)....Pages 21-37
TLR4 Ligands: Single Molecules and Aggregates (Andra B. Schromm, Klaus Brandenburg)....Pages 39-56
CD14: Not Just Chaperone, But a Key-Player in Inflammation (Marco Di Gioia, Ivan Zanoni)....Pages 57-78
Toll-Like Receptor 4 Interactions with Neisseria (Myron Christodoulides)....Pages 79-91
Toll-Like Receptor 4 Activation by Damage-Associated Molecular Patterns (DAMPs) (Monica Molteni, Carlo Rossetti)....Pages 93-103
TLR4 in Neurodegenerative Diseases: Alzheimer’s and Parkinson’s Diseases (Claudia Balducci, Gianluigi Forloni)....Pages 105-118
TLR4-Mediated Neuroinflammation in Human Induced Pluripotent Stem Cells and Cerebral Organoids (Massimiliano De Paola)....Pages 119-127
The Role of TLR4 in Neural Stem Cells–Mediated Neurogenesis and Neuroinflammation (Lidia De Filippis, Francesco Peri)....Pages 129-141
Toll-Like Receptor 4 and the World of microRNAs (Monica Molteni, Carlo Rossetti)....Pages 143-157
Metabolic Reprogramming of Myeloid Cells Upon TLR4 Stimulation (Laure Perrin-Cocon, Anne Aublin-Gex, Vincent Lotteau)....Pages 159-174

✦ Subjects

Life Sciences; Receptors; Immunology; Medical Microbiology; Infectious Diseases; Cancer Research

📜 SIMILAR VOLUMES

The Role of Toll-Like Receptor 4 in Infe

📁 The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation

✍ Carlo Rossetti, Francesco Peri 📂 Library 📅 2020 🏛 Springer 🌐 English

<div></div><div>TLR4 is one of the most important innate immunity receptors, its function mainly consisting in the activation of inflammatory pathways in response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). <p

Toll-like Receptors: Roles in Infection

📁 Toll-like Receptors: Roles in Infection and Neuropathology

✍ Tammy Kielian (auth.), Tammy Kielian (eds.) 📂 Library 📅 2009 🏛 Springer-Verlag Berlin Heidelberg 🌐 English

will follow

Toll-like Receptors: Roles in Infection

📁 Toll-like Receptors: Roles in Infection and Neuropathology

✍ Tammy (Ed.) Kielian, Tammy Kielian 📂 Library 📅 2009 🏛 Springer Berlin Heidelberg 🌐 English

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding b

Toll-like Receptors: Roles in Infection

📁 Toll-like Receptors: Roles in Infection and Neuropathology

✍ Tammy Kielian (auth.), Tammy Kielian (eds.) 📂 Library 📅 2009 🏛 Springer-Verlag Berlin Heidelberg 🌐 English

will follow

Sepsis and Non-infectious Systemic Infla

📁 Sepsis and Non-infectious Systemic Inflammation

✍ Jean-Marc Cavaillon, Christophe Adrie 📂 Library 📅 2008 🏛 Wiley-VCH 🌐 English

Providing definitions, clinical features and epidemiology, Sepsis and Non-infectious Systemic Inflammation adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, this unique handbook and reference work is the first to combine sepsis and non-infecti

Toll-like Receptors in Inflammation

📁 Toll-like Receptors in Inflammation

✍ Kasper Hoebe, Bruce Beutler (auth.), Luke A.J. O’Neill, Elizabeth Brint (eds.) 📂 Library 📅 2005 🏛 Birkhäuser Basel 🌐 English

Toll-like receptors (TLRs) are critical mediators of the innate immune response in mammals. This family of receptors recognizes a variety of microbial products or motifs and initiates the host response to infection. Examples include TLR4 which recognizes lipopolysaccharide (LPS) from Gram-nega