The role of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
✍ Scribed by Stephan Brand; Astrid Konrad; Alexander Crispin; Burkhard Göke; Peter Lohse; Thomas Ochsenkühn
- Book ID
- 110087248
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 108 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1078-0998
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## Background: Nod2/card15, the first identified susceptibility gene in crohn's disease (cd), is associated with ileal stenosis and increased frequency of surgery. anti-saccharomyces cerevisiae antibody (asca), a serological marker for cd, is associated with ileal location and a high likelihood for
## Abstract C57BL/10ScCr (Cr) mice carry a deletion of the Toll‐like receptor 4 (__tlr4__) gene (i.e. they are __tlr4__^0/0^) and are thus refractory to LPS effects. Insertion of wild‐type __tlr4__ transgene into the __tlr4__^0/0^ Cr germ line endowed LPS susceptibility in the two transgenic lines