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The Role of the α2 Chain in the Stabilization of the Collagen Type I Heterotrimer: A Study of the Type I Homotrimer in oim Mouse Tissues

✍ Scribed by Christopher A. Miles; Trevor J. Sims; Nancy P. Camacho; Allen J. Bailey

Book ID
117142969
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
186 KB
Volume
321
Category
Article
ISSN
0022-2836

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Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-␣2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-␣1(I) trimer collage