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The Role of the Pore-forming Region in the Regulation of IP3 Receptor by Luminal Ca2+

✍ Scribed by Cai, Shitian; Chen, Wenqian; Zhang, Lin; Chen, Wayne S.R.


Book ID
119205017
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
56 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract In this study we have used saponin to permeabilize platelet membranes in order to test directly the involvement of IP~3~ in regulating internal Ca^2+^ release, and to measure IP~3~ binding to its receptor. Our results indicate that platelet vesicles release Ca^2+^ as early as 3 seconds