The Role of the Interleukin-1–Receptor Antagonist in Blocking Inflammation Mediated by Interleukin-1
✍ Scribed by Dinarello, Charles A.
- Book ID
- 120260959
- Publisher
- Massachusetts Medical Society
- Year
- 2000
- Tongue
- English
- Weight
- 291 KB
- Volume
- 343
- Category
- Article
- ISSN
- 0096-6762
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Interleukin 1 (IL‐1) is a major mediator of inflammation and exerts pleiotropic effects on many systems. To elucidate the role of its endogenous inhibitor, intracellular IL‐1 receptor antagonist (icIL‐1Ra), in mouse skin, we produced an icIL‐1Ra–overexpressing skin carcinoma cell line (
In situ hybridization (ISH) of human glioblastoma tissue sections revealed expression of interleukin-1 (IL-1)a and/or b and IL-1 receptor types I and II (IL-1R I and II) in the majority of cases evaluable. To understand the function of IL-1-family members in human glioblastomas, we have studied 6 gl