The Role of the Hemostatic System in Tumor Growth, Metastasis, and Angiogenesis: Tissue factor is a Bifunctional Molecule Capable of Inducing Both Fibrin Deposition and Angiogenesis in Cancer

α-Difluoromethylornithine induces apopto

α-Difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model

✍ Yutaka Takahashi; Masayoshi Mai; Kenji Nishioka 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 229 KB 👁 1 views

Polyamines are essential in various biological systems such as cellular proliferation including tumor growth, differentiation and neoplastic transformation including carcinogenesis. ␣-Difluoromethylornithine (DFMO) is a specific irreversible inhibitor of ornithine decarboxylase, a key enzyme in poly