The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes
✍ Scribed by Lucie Khemtémourian; Maarten F. M. Engel; John A. W. Kruijtzer; Jo W. M. Höppener; Rob M. J. Liskamp; J. Antoinette Killian
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 219 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1432-1017
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Type 2 (non-insulin-dependent) diabetes is associated with the deposition of islet amyloid. The major formative peptide, islet amyloid polypeptide, has recently been characterised and an abnormality of the structure or expression of this gene is a possible candidate for the inherited component of Ty
The impact of (pancreatic) islet amyloid polypeptide on glucose metabolism and insulin sensitivity was examined in isolated rat livers perfused in a non-recirculating system. Continuous infusion of 10-7mol/1 islet amyloid polypeptide affected neither basal nor glucagon (10-9 mol/1)stimulated glucose